Evidence for an immunoglobulin-dependent antigen-specific helper T cell
- PMID: 73181
- PMCID: PMC431990
- DOI: 10.1073/pnas.74.10.4582
Evidence for an immunoglobulin-dependent antigen-specific helper T cell
Abstract
Evidence from various systems suggests that thymus-derived lymphocytes can affect the quality of antibody responses by recognizing various portions of the immunoglobulin receptor of bone-marrow-derived thymus-independent lymphocytes. A model for this process is proposed involving two antigen-specific mature T helper cells, one of which also is specific for immunoglobulin determinants. These two cells act synergistically. Evidence from adoptive secondary antibody responses demonstrates that both cells are antigen-specific T cells and that the immunoglobulin-recognizing T helper cell is absent from experimentally agammaglobulinemic mice. This cell is termed an "immunoglobulin-dependent T cell" because its activation requires the presence of immunoglobulin.
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