Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 1981 Nov 15;37(11):1182-3.
doi: 10.1007/BF01989908.

Etamsylate as inhibitor of prostaglandin biosynthesis in pregnant human myometrium in vitro

L Kovács, G Falkay
Comparative Study

Etamsylate as inhibitor of prostaglandin biosynthesis in pregnant human myometrium in vitro

L Kovács et al. Experientia. .

Abstract

The effects of etamsylate on prostaglandin (PG) biosynthesis in microsomes of pregnant human myometrium in vitro have been determined, and compared with those of indomethacin. Both drugs inhibited PG biosynthesis, indomethacin being the more potent inhibitor of the two. Etamsylate inhibited synthesis of 6-oxo-PGF1 alpha, PGF2 alpha, PGE2, and thromboxane B2; increasing the concentration of etamsylate increased the inhibition of synthesis. It is suggested that etamsylate has no anti-cyclo-oxygenase activity, but acts by inhibiting the activity of prostacyclin synthetase, endoperoxide reductase, endoperoxide isomerase, and thromboxane synthetase.

PubMed Disclaimer

References

    1. Pharmacol Rev. 1974 Mar;26(1):33-67 - PubMed
    1. Contracept Deliv Syst. 1980 Apr;1(2):155-9 - PubMed
    1. Life Sci. 1978 Dec 31;23(27-28):2689-96 - PubMed
    1. Biol Reprod. 1977 Feb;16(1):39-56 - PubMed
    1. Gynecol Invest. 1978;9(4):161-5 - PubMed

Publication types