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. 1981 Aug;34(8):1033-8.
doi: 10.7164/antibiotics.34.1033.

New rifamycins modified at positions 3 and 4. Synthesis, structure and biological evaluation

L Marsili, C R Pasqualucci, A Vigevani, B Gioia, G Schioppacassi, G Oronzo
Free article

New rifamycins modified at positions 3 and 4. Synthesis, structure and biological evaluation

L Marsili et al. J Antibiot (Tokyo). 1981 Aug.
Free article

Abstract

A number of semisynthetic rifamycin derivatives modified at positions 3 and/or 4, belonging to general structures 3, 5, and 6 (see Scheme 1), have been prepared. The synthesis, structure and antimicrobial evaluation of the new compounds are described. All the derivatives have "in vitro" antibacterial activities well comparable with that of rifampicin.

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