The results of study of pertussis component of DPT vaccine produced in USSR and some other countries

Abstract

The paper presents the results of testing of 16 vaccines under the letter code from 8 countries received from WHO. These vaccines differed both in toxicity and potency. Six lots contained from 1.12 to 6.29 IPU/ml, i. e. they did not meet WHO requirements for pertussis vaccine. To determine toxic properties of the vaccines in mouse body weight gain test it is more reasonable to use one, but not half an individual immunizing dose. According to all data the absence of correlation between protective and toxic properties of the vaccines was quite definitely revealed. Vaccines from USSR (N, O, P) showed the optimal results for all tests. The limited observations on reactogenicity of vaccines N and O (both produced minor reactions) have brought out the tendency of correlation between the data of laboratory tests and reactogenicity rates of vaccines. The necessity for further investigations to confirm these findings is emphasized.