Epithelial lesions of bladder mucosa following ureteral reimplantation

Abstract

We report on 3 children who underwent ureteral reimplantation. Postoperatively, each patient had persistent, irritative, lower tract symptoms and continuous or recurring urinary infections, with or without gross hematuria. Because of these symptoms cystoscopy was done in 2 children and the third child under went repeat ureteral reimplantation because of persistent vesicoureteral reflux. At operation single or multiple hyperplastic, sessile lesions of the urothelium, not evident at the time of initial ureteral reimplantation, were discovered in each child. Histologically, these lesions showed proliferative and metaplastic glandular epithelial changes. Treatment consisted of transurethral fulguration and long-term antimicrobial medication plus partial cystectomy and topical intravesical chemotherapy for recurrent lesions in 1 child. The etiology of these epithelial lesions, although uncertain, is believed to be a response to long-standing inflammation.