Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1981 Nov;7(6):699-712.
doi: 10.1007/BF01538758.

Specific chromosome loss associated with the expression of tumorigenicity in human cell hybrids

E J Stanbridge, R R Flandermeyer, D W Daniels, W A Nelson-Rees

Specific chromosome loss associated with the expression of tumorigenicity in human cell hybrids

E J Stanbridge et al. Somatic Cell Genet. 1981 Nov.

Abstract

Four related nontumorigenic and tumorigenic HeLa x fibroblast intraspecific human hybrid cell lines were analyzed to determine whether specific chromosome(s) are associated with the control of tumorigenic expression. The loss of one copy each of both chromosome 11 and chromosome 14 were associated, with a high degree of statistical significance, with the expression of tumorigenicity in two segregants derived from the original nontumorigenic hybrid population. Although the parental origin of the chromosomes could not be established in this study, our preliminary results suggest that complex, genetically determined, regulatory interactions may operate in the control of neoplastic expression.

PubMed Disclaimer

Publication types