Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1981 Aug 1;197(2):523-6.
doi: 10.1042/bj1970523.

Identification and characterization of a phospholipase C activity in resident mouse peritoneal macrophages. Inhibition of the enzyme by phenothiazines

P D Wightman, M E Dahlgren, J C Hall, P Davies, R J Bonney

Identification and characterization of a phospholipase C activity in resident mouse peritoneal macrophages. Inhibition of the enzyme by phenothiazines

P D Wightman et al. Biochem J. .

Abstract

Resident mouse peritoneal macrophages contain a phospholipase C of high activity that is specific for phosphatidylinositol. The activity has a neutral pH optimum, is Ca(2+)-dependent and has a maximum reaction velocity of 525nmol/h per mg of protein. Certain phenothiazines are potent inhibitors of this activity.

PubMed Disclaimer

References

    1. Biochem Pharmacol. 1979 Aug 15;28(16):2471-8 - PubMed
    1. Immunology. 1979 Jul;37(3):689-96 - PubMed
    1. Biochem J. 1979 Nov 15;184(2):345-54 - PubMed
    1. Prostaglandins. 1979 Oct;18(4):605-16 - PubMed
    1. J Exp Med. 1980 Aug 1;152(2):324-35 - PubMed