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. 1981 Sep 1;197(3):771-3.
doi: 10.1042/bj1970771.

Identification of aspirinase with one of the carboxylesterases requiring a thiol group

K N White, D B Hope

Identification of aspirinase with one of the carboxylesterases requiring a thiol group

K N White et al. Biochem J. .

Abstract

Aspirin-hydrolysing activity in guinea-pig liver is located mainly in the microsomal fraction. This activity was found by electrophoresis to be due to a single carboxylesterase band, out of 12 bands revealed with alpha-naphthyl acetate as substrate. The activity is inhibited completely and irreversibly by the carboxylesterase inhibitor bis-(-4-nitrophenyl) hydrogen phosphate, and also by thiol-blocking reagents.

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References

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