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. 1981 Dec;19(12):1189-91.
doi: 10.1515/cclm.1981.19.12.1189.

Gas-liquid chromatographic determination of mexiletine in human serum with nitrogen sensitive detection

S M Elfving, E H Svens, E E Leskinen

Gas-liquid chromatographic determination of mexiletine in human serum with nitrogen sensitive detection

S M Elfving et al. J Clin Chem Clin Biochem. 1981 Dec.

Abstract

A simple and rapid method for the quantitative determination of mexiletine, using gas-liquid chromatography with nitrogen sensitive detection, is described. Only one extraction step is needed, the recovery is between 92-96% and the precision varies between 2.0--5.5%. The lower limit of detection reached 0.5 micro mol/1. During routine handling the method was easy, quick and cheap.

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