Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1981 Nov;4(11):879-85.
doi: 10.1248/bpb1978.4.879.

A pharmacokinetic analysis program (multi) for microcomputer

K Yamaoka, Y Tanigawara, T Nakagawa, T Uno

A pharmacokinetic analysis program (multi) for microcomputer

K Yamaoka et al. J Pharmacobiodyn. 1981 Nov.

Abstract

A nonlinear least squares program (MULTI) for microcomputers was developed. The program is written in BASIC programming language. Four algorithms, (1) Gauss-Newton method, (2) damping Gauss-Newton method, (3) modified Marquardt method and (4) simplex method, can be used for nonlinear curve fitting in MULTI. Up to five pharmacokinetic equations, which are voluntarily defined by the user, are simultaneously fitted to observed time courses. The executions of MULTI are demonstrated for time courses of ampicillin and oxacillin in man.

PubMed Disclaimer

LinkOut - more resources