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Comparative Study
. 1981 Nov;12(5):691-4.
doi: 10.1111/j.1365-2125.1981.tb01291.x.

Determination of nomifensine plasma concentrations: a comparison of radioimmunoassay and gas chromatography

I M McIntyre, T R Norman, G D Burrows, K P Maguire
Comparative Study

Determination of nomifensine plasma concentrations: a comparison of radioimmunoassay and gas chromatography

I M McIntyre et al. Br J Clin Pharmacol. 1981 Nov.

Abstract

1 A gas-liquid chromatography (g.l.c.) method for measurement of the antidepressant nomifensine was developed and compared for precision, accuracy, sensitivity and convenience with radioimmunoassay (RIA). 2 No significant difference was found between the two techniques for unconjugated nomifensine (y = 1.07x = 2.7; r = 0.996) or total nomifensine (y = 1.;02x + 0.02; r = 0.999). 3 RIA proved more sensitive than g.l.c. (detection limit of RIA being 1 microgram/l and g.l.c. 5 micrograms/l). 4 RIA was found to be a more convenient technique (up to 50 samples per day with RIA, and 16 samples with g.l.c.).

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References

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    1. J Chromatogr. 1977 Apr 11;134(2):524-8 - PubMed
    1. Arzneimittelforschung. 1978;28(1):58-64 - PubMed

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