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. 1981 Oct:41:189-93.
doi: 10.1289/ehp.8141189.

Mutagenicity studies of vinyl chloride

J D Fabricant, M S Legator

Mutagenicity studies of vinyl chloride

J D Fabricant et al. Environ Health Perspect. 1981 Oct.

Abstract

Mutagenicity studies in both man and in test organisms clearly demonstrate positive mutagenic activity of vinyl chloride. In terms of the mutagenicity studies using a variety of in vitro procedures covering both eukaryotes and prokaryotes, positive effects were found. Cytogenetic in vivo studies in animals and in humans indicate not only somatic mutations, but also germinal effects with this chemical.

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