Murine immune memory to a TI-2 antigen, DNP-Ficoll: carrier-specificity, genetic enhancement and phenotypic dominant inheritance
- PMID: 7334216
- DOI: 10.1111/j.1744-313x.1981.tb00953.x
Murine immune memory to a TI-2 antigen, DNP-Ficoll: carrier-specificity, genetic enhancement and phenotypic dominant inheritance
Abstract
C3H/HeN x NZB/BIN F1 mice were primed and challenged with DNP-Ficoll, a thymic independent (TI-2) antigen. They developed strong IgM and IgG carrier-specific memory responses: DNP-pneumococcal polysaccharide or DNP-haemocyanin challenge did not elicit memory responses. The IgG response component appeared to be inherited dominantly from the C3H/HeN parent. The IgM component resulted from genetic enhancement.