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. 1981 Nov-Dec;44(6):696-700.
doi: 10.1021/np50018a014.

Anticancer indole alkaloids of Rhazya stricta

S Mukhopadhyay, G A Handy, S Funayama, G A Cordell

Anticancer indole alkaloids of Rhazya stricta

S Mukhopadhyay et al. J Nat Prod. 1981 Nov-Dec.

Abstract

The leaves and roots of Rhazya stricta (Apocynaceae) yielded four indole alkaloids. Three of these isolated, vallesiachotamine (1), sewarine (3) and tetrahydrosecamine (4), displayed cytotoxic activity; polyneuridine (2) was not reported previously from this species. Tetrahydrosecaminediol (5), its acetate 6, and didemethoxycarbonyl-tetrahydrosecamine (7) were prepared from tetrahydrosecamine (4) by chemical reactions. The diol 5 was highly cytotoxic.

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