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Case Reports
. 1981 Dec;18(6):442-7.
doi: 10.1136/jmg.18.6.442.

Translocation (X;6) in a female with Duchenne muscular dystrophy: implications for the localisation of the DMD locus

M Zatz, A M Vianna-Morgante, P Campos, A J Diament
Case Reports

Translocation (X;6) in a female with Duchenne muscular dystrophy: implications for the localisation of the DMD locus

M Zatz et al. J Med Genet. 1981 Dec.

Abstract

A female with Duchenne muscular dystrophy who was a carrier of a balanced translocation t(X;6)(p21;q21) is reported. Four other previously described (X;A) translocations associated with DMD share with the present case a breakpoint at Xp21. The extremely low probability of five independent (X;A) translocations having a breakpoint at Xp21 points to a non-rand association of this site with the DMD phenotype. A DMD locus at Xp21 could be damaged by the translocation, giving rise to Duchenne muscular dystrophy. Alternatively, a pre-existing DMD gene could weaken the chromosome, favouring breaks at Xp21.

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References

    1. Ann Hum Genet. 1971 Feb;34(3):229-50 - PubMed
    1. Lancet. 1971 Oct 30;2(7731):971-2 - PubMed
    1. Am J Hum Genet. 1972 Sep;24(5):583-97 - PubMed
    1. Chromosoma. 1972;38(4):341-65 - PubMed
    1. Am J Hum Genet. 1973 Jan;25(1):57-61 - PubMed

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