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. 1981 Nov;11(5):425-8.
doi: 10.1007/BF02004701.

Alpha-methylhistamine methylation by histamine methyltransferase

L B Hough, J K Khandelwal, T W Mittag

Alpha-methylhistamine methylation by histamine methyltransferase

L B Hough et al. Agents Actions. 1981 Nov.

Abstract

Enzymatic methylation of histamine and analogues by histamine methyltransferase (HMT) was studied. Incubation of histamine or alpha-methylhistamine with HMT and S-adenosylmethionine was shown by GC-MS to yield tele-methyl and alpha-methyl-tele-methyl-histamine, respectively. Kinetic analysis of the reactions indicated that both substrates exhibited equivalent Vmax values, but that histamine's Km was ten-fold lower than that of alpha-methylhistamine. These results indicate that alpha-methylhistamine can be methylated as effectively as histamine, and may be a useful tool in further studies of HMT.

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