Can multiple low-density immunoadsorbents and 'negative' distance matrices help predict the three-dimensional structure of any globular protein?
- PMID: 7337710
- PMCID: PMC1163365
- DOI: 10.1042/bj1990277
Can multiple low-density immunoadsorbents and 'negative' distance matrices help predict the three-dimensional structure of any globular protein?
Abstract
Chemical cross-linking of a protein immobilized on multiple, site-specific, monoclonal, chemically modified antibody matrices combined with analysis of data on a distance matrix is likely to yield sufficient positive and 'negative' long-range distance information to help predict the three dimensional structure of any single-chain globular protein.
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