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. 1981 Dec;11(6-7):736-40.
doi: 10.1007/BF01978798.

Drug metabolism in rats with arthritis induced by 6-sulfanilamidoindazole (6-SAI)

D Müller, R Hirschelmann

Drug metabolism in rats with arthritis induced by 6-sulfanilamidoindazole (6-SAI)

D Müller et al. Agents Actions. 1981 Dec.

Abstract

Hexobarbital sleeping time was prolonged and ethylmorphine N-demethylation was inhibited after a single dosage or seven administration of 6-SAI to old rats. These effects were independent of the development of arthritis. Changes in cytochrome P-450 concentration after 6-SAI treatment were insignificant and thus not responsible for the decrease in drug metabolism. In vitro 6-SAI inhibited ethylmorphine N-demethylation; the inhibition was of a mixed type. 6-SAI bound to cytochrome P-450 and induced a type II spectrum. The magnitude of hexobarbital-induced type I spectral changes was diminished by 6-SAI. It is concluded that 6-SAI inhibits cytochrome P-450-dependent drug metabolism by binding to cytochrome P-450.

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