doi: 10.1046/j.1468-2982.1981.0104223.x.
Effects of 5-hydroxytryptamine and ergotamine on human superficial temporal artery
- PMID: 7347625
- DOI: 10.1046/j.1468-2982.1981.0104223.x
Item in Clipboard
Effects of 5-hydroxytryptamine and ergotamine on human superficial temporal artery
Cephalalgia.
1981 Dec.
Abstract
Isometric tension was recorded in ring preparations of human superficial temporal arteries contracted by noradrenaline (NA), 5-hydroxytryptamine (5-HT), and ergotamine. In contrast to NA and 5-HT, ergotamine induced long-lasting contractions refractive to additional stimulations and resistant to repeated wash-out. When tested against 5-HT, ergotamine acted as a non-competitive antagonist. When repeating the 5-HT stimulations (4.7 x 10(-5) M) the contractile response decreased indicating tachyphylaxis to this agent. As ergotamine revealed both a vasoconstrictive and a 5-HT-blocking activity, the beneficial effect in migraine may be by an interference during both the vasoconstrictory and vasodilatory phases.
Similar articles
-
Effects of ergotamine on isolated human vessels.Arch Int Pharmacodyn Ther. 1981 Aug;252(2):241-52. Arch Int Pharmacodyn Ther. 1981. PMID: 7305561
-
Influence of pizotifen and ergotamine on the venoconstrictor effect of 5-hydroxytryptamine and noradrenaline in man.Eur J Clin Pharmacol. 1983;25(6):759-62. doi: 10.1007/BF00542515. Eur J Clin Pharmacol. 1983. PMID: 6662174
-
Regional differences in the responsiveness of isolated arteries from cattle, dog and man.Agents Actions. 1977 Sep;7(3):383-9. doi: 10.1007/BF01969572. Agents Actions. 1977. PMID: 596322
-
Ergotamine: its use in the treatment of migraine and its complications.Acta Neurol (Napoli). 1992 Apr;14(2):140-6. Acta Neurol (Napoli). 1992. PMID: 1329442 Review.
-
Role of some biogenic substances in migraine and relevant mechanism in antimigraine action of ergotamine--studies in an experimental model for migraine.Headache. 1974 Jan;13(4):142-63. doi: 10.1111/j.1526-4610.1974.hed1304142.x. Headache. 1974. PMID: 4149297 Review. No abstract available.
Cited by
-
Genetic Reprogramming of the Ergot Alkaloid Pathway of Metarhizium brunneum.Appl Environ Microbiol. 2020 Sep 17;86(19):e01251-20. doi: 10.1128/AEM.01251-20. Print 2020 Sep 17. Appl Environ Microbiol. 2020. PMID: 32769181 Free PMC article.
-
Dihydroergotamine: discrepancy between arterial, arteriolar and pharmacokinetic data.Br J Clin Pharmacol. 2001 Jul;52(1):45-51. doi: 10.1046/j.0306-5251.2001.01415.x. Br J Clin Pharmacol. 2001. PMID: 11453889 Free PMC article. Clinical Trial.
-
What can be learned from the history of recurrence in migraine? A comment.J Headache Pain. 2009 Oct;10(5):311-5. doi: 10.1007/s10194-009-0144-0. Epub 2009 Aug 25. J Headache Pain. 2009. PMID: 19705060 Free PMC article. Review.
-
Interaction of Isoflavones and Endophyte-Infected Tall Fescue Seed Extract on Vasoactivity of Bovine Mesenteric Vasculature.Front Nutr. 2015 Oct 19;2:32. doi: 10.3389/fnut.2015.00032. eCollection 2015. Front Nutr. 2015. PMID: 26539437 Free PMC article.
-
Contractile Response of Bovine Lateral Saphenous Vein to Ergotamine Tartrate Exposed to Different Concentrations of Molecularly Imprinted Polymer.Toxins (Basel). 2018 Jan 30;10(2):58. doi: 10.3390/toxins10020058. Toxins (Basel). 2018. PMID: 29385697 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Research Materials
