[Effect of hyperoxia combined with hydrocortisone administration on respiration of rat brain mitochondria]
[Article in
Russian]
- PMID: 734976
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[Effect of hyperoxia combined with hydrocortisone administration on respiration of rat brain mitochondria]
[Article in
Russian]
Vopr Med Khim.
1978 Nov-Dec.
Abstract
After exposure of rats in oxygen atmosphere under pressure of 3 kgs/cm2 within 2 hrs phosphorylating respiration, respiratory control and the ratio ADP/O were decreased, while time of phosphorylation was increased in mitochondria of brain cortex. Content of 11-hydroxycorticosteroids was increased in blood plasma. Reaction of adrenal cortex to hyperbaric oxygenation was inhibited, if hydrocortisone was administered into animals within 1 hr before the treatment; in this case the patterns of mitochondrial function studied were similar to normal values.
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