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. 1980 Jan 3;283(5742):41-6.
doi: 10.1038/283041a0.

A UGA termination suppression tRNATrp active in rabbit reticulocytes

A I Geller, A Rich

A UGA termination suppression tRNATrp active in rabbit reticulocytes

A I Geller et al. Nature. .

Abstract

A tRNATrp was purified from rabbit reticulocytes which suppresses the UGA termination codon of beta-haemoglobin mRNA. Evidence is presented that the beta-haemoglobin readthrough protein is found in reticulocyte translations and intact cells. Some natural readthrough proteins perform essential functions; they are synthesised through suppression of UGA or UAG but not UAA termination codons.

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