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. 1980 Feb 14;283(5748):669-70.
doi: 10.1038/283669a0.

Osteoclasts derived from haematopoietic stem cells

P Ash, J F Loutit, K M Townsend

Osteoclasts derived from haematopoietic stem cells

P Ash et al. Nature. .

Abstract

The origins of the multinucleated osteoclast have been controversial, with osteogenic precursors and haematopoietic stem cells as candidates. Recent evidence for the latter is persuasive but circumstantial. We report here direct evidence obtained in radiation chimaeras from a natural cytoplasmic cell marker transmitted by the donated haematopoietic stem cell.

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