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Clinical Trial
. 1980 Jan;9(1):27-31.
doi: 10.1111/j.1365-2125.1980.tb04792.x.

Plasma noradrenaline concentration in essential hypertension during long-term beta-adrenoceptor blockade with oxprenolol

D H Jones, J Daniel, C A Hamilton, J L Reid
Clinical Trial

Plasma noradrenaline concentration in essential hypertension during long-term beta-adrenoceptor blockade with oxprenolol

D H Jones et al. Br J Clin Pharmacol. 1980 Jan.

Abstract

1. Chronic beta-adrenoceptor blockade with oxprenolol causes elevation of plasma noradrenaline levels, as compared with placebo, despite a significant fall in blood pressure and pulse rate. 2. The plasma noradrenaline concentration is not influenced by the frequency of administration or the formulation of the drug. 3. Plasma noradrenaline levels are not correlated with the plasma concentration of the drug. 4. The changes in plasma noradrenaline concentrations support a peripheral rather than central mechanism of action of beta-adrenoceptor blockers in man.

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