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. 1980 Feb;9(2):183-6.
doi: 10.1111/j.1365-2125.1980.tb05831.x.

Elevated blood histamine levels and mast cell degranulation in solar urticaria

J L Hawk, R A Eady, A V Challoner, A Kobza-Black, T M Keahey, M W Greaves

Elevated blood histamine levels and mast cell degranulation in solar urticaria

J L Hawk et al. Br J Clin Pharmacol. 1980 Feb.

Abstract

1 Ultraviolet radiation (UVR)-induced wealing was studied in four patients with solar urticaria, whose measured action spectra were within the range 300 to 700 nm. 2 Elevated histamine levels were found in blood draining wealed skin in all four patients. 3 Histological and electron microscopial studies of the irradiated skin showed evidence of mast cell degranulation. 4 These findings demonstrate an association between histamine release from mast cells and wealing in solar urticaria, and should encourage evaluation of drugs which suppress histamine release in this disorder.

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