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. 1980 Jan;68(1):17-8.
doi: 10.1111/j.1476-5381.1980.tb10692.x.

Effects of 5-hydroxytryptophol, a 5-hydroxytryptamine metabolite, on isolated cerebral arteries of the dog

L H Wang Fu, S Hayashi, N Toda

Effects of 5-hydroxytryptophol, a 5-hydroxytryptamine metabolite, on isolated cerebral arteries of the dog

L H Wang Fu et al. Br J Pharmacol. 1980 Jan.

Abstract

5-Hydroxytryptophol (5-HTOL) caused a dose-dependent contraction of helically-cut strips of dog cerebral arteries. The 5-HTOL-induced contraction was suppressed by cinanserin, as was the contraction induced by 5-hydroxytryptamine (5-HT). Treatment with 5-HTOL shifted the dose-response curve for 5-HT to the right and downward in a dose-dependent manner, but did not attenuate the contractile response to prostaglandin F2a. It may be concluded that 5-HTOL elicits cerebroarterial contractions by activating tryptaminergic receptors and also interferes with the action of 5-HT on the receptors.

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