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Comparative Study
. 1980 Mar 15;45(6):1340-3.
doi: 10.1002/1097-0142(19800315)45:6<1340::aid-cncr2820450612>3.0.co;2-7.

Pulmonary abnormalities in patients intravenously receiving the methanol extraction residue (MER) of Bacillus Calmette-Guerin

J R Quesada, H I Libshitz, E M Hersh, J U Gutterman
Comparative Study

Pulmonary abnormalities in patients intravenously receiving the methanol extraction residue (MER) of Bacillus Calmette-Guerin

J R Quesada et al. Cancer. .

Abstract

Eight of 64 patients receiving intravenous administration of methanol extraction residue (MER) of Bacillus Calmette-Guerin (BCG), developed miliary-type pulmonary parenchymal changes. The clinical and radiological characteristics are described. An increased incidence was noted in patients with a history of previous BCG exposure or with positive PPD skin reactivity. Spontaneous resolution was observed upon discontinuation of MER. These changes most likely respresent a granulomatous inflammatory process, although no histological confirmation was obtained.

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