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. 1980 Feb;43(2):102-5.
doi: 10.1136/jnnp.43.2.102.

Relation between benign course of multiple sclerosis and low-grade humoral immune response in cerebrospinal fluid

Relation between benign course of multiple sclerosis and low-grade humoral immune response in cerebrospinal fluid

L Stendahl-Brodin et al. J Neurol Neurosurg Psychiatry. 1980 Feb.

Abstract

The prognosis in multiple sclerosis (MS) is related to the presence of an abnorma humoral immune response within the central nervous system: 14/17 MS patients (82%) without oligoclonal CSF IgG displayed no or slight disability after a mean duration of MS of 17 years, while 53% of 88 patients with oligoclonal CSF IgG had a benign course after a mean duration of 13 years (p less than 0.05). A benign course also was more often accompanied by a normal CSF IgG index. MS patients without oligoclonal CSF IgG had elevated CSF/serum ratios of albumin in 6%, and of the complement factors C3 in 0% and C4 in 6%, as against 20%, 27% and 37%, respectively, in MS patients with oligoclonal CSF IgG.

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References

    1. Neurology. 1977 Mar;27(3):273-7 - PubMed
    1. Neurology. 1978 Sep;28(9 Pt 2):76-83 - PubMed
    1. Neurology. 1970 Oct;20(10):982-90 - PubMed
    1. Arch Neurol. 1971 Oct;25(4):326-44 - PubMed
    1. Z Neurol. 1972;203(2):119-32 - PubMed