doi: 10.1080/0002889778507877.
Biological monitoring of exposure to styrene by analysis of combined urinary mandelic and phenylglyoxylic acids
- PMID: 735998
- DOI: 10.1080/0002889778507877
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Biological monitoring of exposure to styrene by analysis of combined urinary mandelic and phenylglyoxylic acids
Am Ind Hyg Assoc J.
1978 Nov.
Abstract
Human volunteers were exposed in an experimental chamber to styrene (4 or 8 hours at 40 to 200 ppm) in order to obtain a quantitative relationship between exposure and urinary elimination of the metabolites mandelic and phenylglyoxylic acids (MA and PGA). For the analysis of PGA a new GC-method was used, based on reductive transformation of the relatively instable PGA into MA, which is stable enough for shipping and handling until final processing. The analysis of the post-exposure elimination shows that spot urine sampled in the morning after exposure and analysed for the sum of MA and PGA is the most reliable index for reflecing a preceding exposure to styrene.
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