Nuclear activation of carbon tetrachloride and chloroform
- PMID: 7361000
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Nuclear activation of carbon tetrachloride and chloroform
Res Commun Chem Pathol Pharmacol.
1980 Jan.
Abstract
Highly purified rat liver nuclear preparations are able to activate anaerobically CCl4 and aerobically CHCl3 to reactive metabolites that bind to lipids and proteins. Activity in nuclear preparations is smaller than in microsomes but of the same order of magnitude.
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