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. 1980 Jan;32(1):103-11.

HLA and the inheritance of multiple sclerosis: linkage analysis of 72 pedigrees

J L Tiwari, S E Hodge, P I Terasaki, M A Spence

HLA and the inheritance of multiple sclerosis: linkage analysis of 72 pedigrees

J L Tiwari et al. Am J Hum Genet. 1980 Jan.

Abstract

Linkage analysis of 72 pedigrees by the maximum-likelihood method provides evidence of linkage between HLA and the hypothesized multiple sclerosis susceptibility gene (MSSG) for both the dominant and recessive models of inheritance and for penetrance values ranging from 5%--65% (or higher). This MSSG, if it exists, is most likely located at 15%--20% recombination units from the HLA complex, probably on the B-D side. The analysis also shows that there is no heterogeneity in the estimates of linkage, and lod scores are not artifically inflated because of the association of multiple sclerosis (MS) with HLA-B7.

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