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. 1976 Mar 27;1(7961):672-4.
doi: 10.1016/s0140-6736(76)92781-1.

Mitochondrial calcium overload: A general mechanism for cell-necrosis in muscle diseases

K Wrogemann, S D Pena

Mitochondrial calcium overload: A general mechanism for cell-necrosis in muscle diseases

K Wrogemann et al. Lancet. .

Abstract

It is suggested that the mechanism of muscle-cell necrosis in various muscle diseases is explained by an increased net influx of calcium into cells which triggers a "vicious cycle" of mitochondrial calcium overloading and energy depletion. If correct, this hypothesis may offer the basis of a more rational treatment of some muscle diseases even before their primary aetiology is known.

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