Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1980 Mar;11(2):115-28.
doi: 10.1016/0020-7101(80)90028-8.

A program library for computing the parameters of linear compartment models in pharmacokinetics

H Poland, R Woloszczak

A program library for computing the parameters of linear compartment models in pharmacokinetics

H Poland et al. Int J Biomed Comput. 1980 Mar.

Abstract

A program library is presented with which explicit solutions of linear compartment models can be fitted to pharmacokinetic experimental data. Use is made of the fact that transport constants can be calculated from the numberical solution of such a problem without ambiguity. The non-linear regression is carried out using the Powell-method. A report of our experience with, e.g. choice of objective function, lag-time, accuracy of the numerical solution is included.

PubMed Disclaimer

Substances

LinkOut - more resources