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. 1980 Mar;23(3):324-6.
doi: 10.1021/jm00177a024.

Synthesis and anticancer activity of nitrosourea derivatives of phensuximide

A M Crider, T M Kolczynski, K M Yates

Synthesis and anticancer activity of nitrosourea derivatives of phensuximide

A M Crider et al. J Med Chem. 1980 Mar.

Abstract

Nitrosourea derivatives 9--13 which utilize phensuximide (1) as the carrier were synthesized as potential central nervous system antitumor agents. The N-(2-chloroethyl)-N-nitrosourea 13 was active in the mouse ependymoblastoma brain-tumor system, as well as the intraperitoneal L1210 leukemia system.

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