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. 1978 Oct;235(2):219-29.

A selective tonic activation of gastrointestinal smooth muscle by substance P

K Milenov, K Nieber, P Oehme
  • PMID: 736699

A selective tonic activation of gastrointestinal smooth muscle by substance P

K Milenov et al. Arch Int Pharmacodyn Ther. 1978 Oct.

Abstract

Mechanical and electrical activity of smooth muscle preparations from fundus, corpus, and antrum of guinea-pig stomach and from distal ileum of guinea-pig were recorded, and the effects of Substance P were examined. Substance P activated selectively the tonic activity of corpus, fundus, and ileum of guinea-pig before and after blockade of phasic contractions. The tonic activation of Substance P is accompanied by increasing of number and amplitude of spike discharges and by decreasing of amplitude of slow potentials in corpus. The tonic activation of Substance P is potentiated parallel with reduction of Ca++ up to 0.6 mmol.

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