[Use of invert sugar, fructose and sorbitol and on their effect on various plasma constituents after intravenous infusion in the dog]

Abstract

Glucose and fructose half-lives following intravenous infusion of 1.0 or 0.5 g/body weight invertose solution (200 g/l) were established in six Beagle dogs. The average half-lives measured were 7.8 for glucose (variation between 6.0 and 13.5) and 7.5 for fructose (variation between 4.5 and 11.0), all values given in minutes. Administration of invertose instead of glucose for parenteral energy supply proved favourable in various respects. Infusion of invertose was temporarily followed by rises within physiological limits of lactate and pyruvate in the blood and of insulin concentrations in the blood plasma, whereas the levels of free fatty acids declined. A 25-per-cent fructose solution was infused (0.5 g/kg body weight) to three dogs, and the half-lives then measured were six, nine, and 13 minutes. The insulin concentration rose temporarily, while the free fatty acids went down. The same doses of sorbite gave half-lives of 15.5 or 17 minutes. Infusion was followed by temporary increase of fructose and insulin in the blood plasma.