doi: 10.1126/science.7367889.
Opioid and nonopioid mechanisms of stress analgesia
- PMID: 7367889
- DOI: 10.1126/science.7367889
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Opioid and nonopioid mechanisms of stress analgesia
Science.
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Abstract
Inescapable foot shock in rats caused profound analgesia that was antagonized by naloxone or dexamethasone when shock was delivered intermittently for 30 minutes, but not when it was delivered continuously for 3 minutes. Thus, depending only on its temporal characteristics, foot-shock stress appears to activate opioid or nonopioid analgesia mechanisms. Certain forms of stress may act as natural inputs to an endogenous opiate analgesia system.
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