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. 1980 Mar 22;57(12):458-60.

The effect of delta-aminolevulinic acid on the synthesis and metabolism of GABA in rabbit brain homogenates

D M Becker, E Cayanis, S Kramer
  • PMID: 7367997

The effect of delta-aminolevulinic acid on the synthesis and metabolism of GABA in rabbit brain homogenates

D M Becker et al. S Afr Med J. .

Abstract

The porphyrin precursor delta-aminolevulinic acid (delta-ALA) is a structural analogue of the putative amino acid neurotransmitter, gamma-aminobutyric acid (GABA). This study has demonstrated that delta-ALA has no effect on glutamate decarboxylase activity and only a small inhibitory effect of GABA aminotransferase activity. This would suggest that if accumulation of delta-ALA is related to development of the acute attack of porphyria, it is not via an effect on GABA synthesis and metabolism.

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