Ultrastructure of pancreatic tumors induced in Syrian hamsters by N-nitroso-2,6-dimethylmorpholine

Abstract

Tumors of the pancreas diagnosed as duct carcinomas and adenomas were induced in Syrian hamsters by intragastric administration of N-nitroso-2,6-dimethylmorpholine (2,6-DMNM). The ultrastructure of the well differentiated tumor cells reflected the morphology of normal duct epithelia while such features were less conspicuous in poorly differentiated neoplasms. Under the light and electron microscopes, the pancreatic tumors closely resembled those induced by N-nitroso-bis(2-hydroxypropyl)amine.