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. 1980 Mar;36(1):69-79.

The crossover experiment for clinical trials

B W Brown Jr
  • PMID: 7370374

The crossover experiment for clinical trials

B W Brown Jr. Biometrics. 1980 Mar.

Abstract

The two-period crossover or changeover design for clinical trials is compared with other simple designs in terms of statistical precision and cost. The sensitivity of the crossover to bias due to carryover effects is examined. The feasibility of using the crossover data to test for the existence of carryover effects is investigated and found to be uneconomical. A numerical example is presented.

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