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. 1980 Jun 13;208(4449):1284-6.
doi: 10.1126/science.7375942.

Clinical radioimmunodetection of cancer with radioactive antibodies to human chorionic gonadotropin

D M Goldenberg, E E Kim, F H DeLand, J R van Nagell Jr, N Javadpour

Clinical radioimmunodetection of cancer with radioactive antibodies to human chorionic gonadotropin

D M Goldenberg et al. Science. .

Abstract

Injection of iodine-131-labeled goat immunoglobulin G antibody to human chorionic gonadotropin (hCG) into patients with hCG-secreting trophoblastic and germinal tumors permitted tumor detection and location by external gamma-ray scintigraphy. Excision of one of the metastatic tumors located by this method indicated a tumor/nontumor ration of 39.29. The method appears to offer a new clinical tool for precisely locating hCG-producing tumors in the body, even when tumor identification by other clinical methods has failed.

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