Circular dichroism studies of keto-bile acids

Abstract

Circular dichroism curves for various saturated bile acid derivatives with carbonyl groups at carbon atoms 3,7, and 12 are presented and it is demonstrated that this method offers a convenient solution for the location of mono and diketo carbonyl groups in the bile acid molecule. From the shapes (n leads to II transition) of these CD curves the precise localization of the carbonyl groups and the stereochemistry of the A/B ring juncture can be determined.