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Comparative Study
. 1980 Feb 15;186(2):621-4.
doi: 10.1042/bj1860621.

Interactions between vasopressin and glucagon on ketogenesis and oleate metabolism in isolated hepatocytes from fed rats

D H Williamson, V Ilic, A F Tordoff, E V Ellington
Comparative Study

Interactions between vasopressin and glucagon on ketogenesis and oleate metabolism in isolated hepatocytes from fed rats

D H Williamson et al. Biochem J. .

Abstract

Vasopressin (10nM) inhibited ketogenesis (56%) in hepatocytes from fed rats when oleate (1 mM) was the substrate, but had no effect with butyrate (10mM). The hormone increased the accumulation of lactate and stimulated the esterification of [1(-14)C]oleate (70%). These effects of vasopressin were reversed by glucagon (10 nM). The physiological implications of these findings are discussed.

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