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Comparative Study
. 1980 Apr;9(4):327-31.
doi: 10.1111/j.1365-2125.1980.tb01058.x.

Induction of delta-aminolaevulinic acid synthase in leucocytes of patients on phenytoin therapy--comparison with changes in rat hepatic tissue

K E McColl, M R Moore, G G Thompson, A Goldberg
Comparative Study

Induction of delta-aminolaevulinic acid synthase in leucocytes of patients on phenytoin therapy--comparison with changes in rat hepatic tissue

K E McColl et al. Br J Clin Pharmacol. 1980 Apr.

Abstract

1 In rats daily phenytoin (DPH) administration resulted in an increase in hepatic cytochrome P450 content. The rise in cytochrome P450 was associated with a temporary increase in the acitvity of hepatic delta-aminolaevulinic acid (ALA) synthase. 2 In patients newly commenced on DPH anticonvulsant therapy the activity of ALA synthase in peripheral leucocytes showed a marked temporary increase during the first 10 days of therapy. 3 These findings suggest that DPH induces a haem-requiring eenzyme system in peripheral leucocytes as well as in hepatic tissue.

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