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. 1980 Feb;61(1):55-60.

Effects of chrysotile asbestos on mononuclear cells in vitro

S Kagamimori, M P Scott, D G Brown, R E Edwards, M M Wagner

Effects of chrysotile asbestos on mononuclear cells in vitro

S Kagamimori et al. Br J Exp Pathol. 1980 Feb.

Abstract

Chrysotile asbestos (400 micrograms/ml) was not found to be cytotoxic towards human blood lymphocytes in culture over a 72 h period, although there was indirect evidence of cytoxicity towards plastic adherent mononuclear cells (PAM). There was significant suppression of 3H-thymidine incorporation into cells cultured with phytohaemagglutinin (PHA) in the presence of fibres. It was found even when chrysotile was added 24 h after PHA. No suppression was found for chrysotile-treated PAM-depleted cultures in comparison to control cultures. Antibody-dependent cell-mediated cytotoxicty (ADCC) was inhibited by the presence of chrysotile, and appeared to be due to prevention of contact between antibody-coated target cells and effector cells.

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