Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1980 Feb;61(1):55-60.

Effects of chrysotile asbestos on mononuclear cells in vitro

S Kagamimori, M P Scott, D G Brown, R E Edwards, M M Wagner

Effects of chrysotile asbestos on mononuclear cells in vitro

S Kagamimori et al. Br J Exp Pathol. 1980 Feb.

Abstract

Chrysotile asbestos (400 micrograms/ml) was not found to be cytotoxic towards human blood lymphocytes in culture over a 72 h period, although there was indirect evidence of cytoxicity towards plastic adherent mononuclear cells (PAM). There was significant suppression of 3H-thymidine incorporation into cells cultured with phytohaemagglutinin (PHA) in the presence of fibres. It was found even when chrysotile was added 24 h after PHA. No suppression was found for chrysotile-treated PAM-depleted cultures in comparison to control cultures. Antibody-dependent cell-mediated cytotoxicty (ADCC) was inhibited by the presence of chrysotile, and appeared to be due to prevention of contact between antibody-coated target cells and effector cells.

PubMed Disclaimer

References

    1. Br J Ind Med. 1960 Oct;17:260-71 - PubMed
    1. Br J Exp Pathol. 1977 Oct;58(5):465-73 - PubMed
    1. J Exp Med. 1972 Jul 1;136(1):128-42 - PubMed
    1. Inhaled Part. 1970;1:437-45 - PubMed
    1. Immunology. 1970 Mar;18(3):405-12 - PubMed