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. 1980 Jun;27(6):810-4.
doi: 10.1038/clpt.1980.115.

Rifampicin and vitamin D metabolism

M J Brodie, A R Boobis, C T Dollery, C J Hillyard, D J Brown, I MacIntyre, B K Park

Rifampicin and vitamin D metabolism

M J Brodie et al. Clin Pharmacol Ther. 1980 Jun.

Abstract

A 2-wk course of rifampicin orally (600 mg/day) in 8 male subjects resulted in a consistent fall in plasma 25-hydroxycholecalciferol (25-OHD) levels of around 70%, accompanied by increased oxidation of antipyrine and 6 beta-hydroxycortisol (indicative of hepatic enzyme induction). Plasma levels of 1,25-dihydroxycholecalciferol, parathyroid hormone, and calcitonin were not altered. The fall in 25-OHD may represent the earliest lesion of drug-induced osteomalacia.

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