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. 1980 Feb;21(2):123-7.
doi: 10.1136/gut.21.2.123.

Plasma clearance of oral and intravenous cholic acid in subjects with and without chronic liver disease

I T Gilmore, R P Thompson

Plasma clearance of oral and intravenous cholic acid in subjects with and without chronic liver disease

I T Gilmore et al. Gut. 1980 Feb.

Abstract

The apparent plasms clearances of tracer amounts of radiolabelled cholic acid given orally or intravenously were compared in 14 control subjects and 20 patients with chronic liver disease. The clearance after oral administration was the more sensitive in detecting chronic liver disease and correlated better with the fasting levels of endogenous serum bile acid. This agrees with the predicted effects on clearance of hepatocellular damage and portal-systemic shunting of blood after the two routes of administration. The estimated hepatic extraction ratio, calculated from the ratio of the oral and intravenous clearances, was 0.77+/-0.02 (mean+/-SEM) in control subjects, 0.64+/-0.03 in patients with anicteric chronic liver disease, and 0.46+/-0.05 in those with icteric chronic liver disease.

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References

    1. J Physiol. 1965 Sep;180(1):67-79 - PubMed
    1. J Physiol. 1967 Apr;189(2):337-50 - PubMed
    1. Eur J Clin Invest. 1970 Mar;1(1):54-64 - PubMed
    1. Gut. 1971 Feb;12(2):145-52 - PubMed
    1. Clin Chim Acta. 1971 Apr;32(2):207-14 - PubMed