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. 1980 Jul 18;209(4454):394-5.
doi: 10.1126/science.7384811.

Opiates and opioid peptides hyperpolarize locus coeruleus neurons in vitro

C M Pepper, G Henderson

Opiates and opioid peptides hyperpolarize locus coeruleus neurons in vitro

C M Pepper et al. Science. .

Abstract

Intracellular recordings were made from locus coeruleus neurons in a brain slice preparation. Opiates and opioid peptides produced a dose-dependent, stereospecific, naloxone-reversible hyperpolarization of the neuronal membrane. This was associated with an increase in membrane conductance.

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