doi: 10.1126/science.7384811.
Opiates and opioid peptides hyperpolarize locus coeruleus neurons in vitro
- PMID: 7384811
- DOI: 10.1126/science.7384811
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Opiates and opioid peptides hyperpolarize locus coeruleus neurons in vitro
Science.
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Abstract
Intracellular recordings were made from locus coeruleus neurons in a brain slice preparation. Opiates and opioid peptides produced a dose-dependent, stereospecific, naloxone-reversible hyperpolarization of the neuronal membrane. This was associated with an increase in membrane conductance.
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