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. 1980;267(1):91-5.
doi: 10.1007/BF00416927.

Arsenic elevates the sister chromatid exchange (SCE) rate in human lymphocytes in vitro

F Zanzoni, E G Jung

Arsenic elevates the sister chromatid exchange (SCE) rate in human lymphocytes in vitro

F Zanzoni et al. Arch Dermatol Res. 1980.

Abstract

The number of sister chromatid exchanges (SCE) per metaphase was determined in normal human lymphocytes by the Hoechst-Giesmsa procedure. The addition of inorganic trivalent arsenic (Na2HAsO4) 10(-6) M and 2 x 10(-6) M induces a significant and dose-dependent increase of SCE. This phenomenon is as sensitive as the evidence of arsenic-induced chromosomal aberrations in vitro.

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