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. 1980 Mar;44(1-3):23-30.
doi: 10.1007/BF00303180.

Are findings with isolated rat livers after short calcium free perfusion relevant for isolated cells?

H Höke, H Krell, E Pfaff

Are findings with isolated rat livers after short calcium free perfusion relevant for isolated cells?

H Höke et al. Arch Toxicol. 1980 Mar.

Abstract

In the isolated liver transient perfusion without calcium results in cholestasis which was characterized by an increased efflux rate across the sinusoidal membrane and inhibition of the concentrative transport of bromosulfophthalein to the canalicular side of the cell. Cholestasis could not be reversed within the usual duration of liver perfusion.

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